Surface Chemistry Dictates the Osteogenic and Antimicrobial Properties of Palladium‐, Platinum‐, and Titanium‐Based Bulk Metallic Glasses

Titanium alloys are commonly used as biomaterials in musculoskeletal applications, but their long-term efficacy can be limited by wear and corrosion, stress shielding, bacterial colonization. As a promising alternative, bulk metallic glasses (BMGs) offer superior strength corrosion resistance, the influence of chemical composition on bioactivity remains largely unexplored. This study, therefore, aims to examine how surface chemistry palladium (Pd)-, platinum (Pt)-, titanium (Ti)-based BMGs steer response biological systems. The governs thermophysical mechanical properties, with Pd-based showing exceptional glass-forming ability suitable for larger implants, all exhibiting significantly lower Young's modulus than Ti-6Al-4 V (Ti64), suggesting potential reduce shielding. Although feature copper depletion at near surface, more stable that Ti64 supports blood biocompatibility. Fibrin network formation is heavily dependent BMGs’ Ti-based support thicker fibrin Ti64. Furthermore, outperform promoting mineralization human bone progenitor cells demonstrate antimicrobial properties against Staphylococcus aureus chemistry-dependent manner, thereby indicating great applications.